USMLE® Content Outline

Last updated: June 29, 2022

General Principles of Foundational Sciencetoggle arrow icon

Biochemistry and molecular biology

Biology of cells

Human development and genetics

Biology of tissue response to disease

Pharmacodynamic and pharmacokinetic processes: general principles

Microbial biology

  • Microbial identification and classification, including principles, microorganism identification, and non-immunologic laboratory diagnosis
  • Bacteria
    • structure (eg, cell walls, composition, appendages, virulence factors, extracellular products, toxins, mechanism of action of toxins)
    • processes, replication, and genetics (eg, metabolism, growth, and regulation)
    • oncogenesis
    • antibacterial agents (eg, mechanisms of action on organism, toxicity to humans, and mechanisms of resistance)
  • Viruses
  • Fungi
    • structure (eg, cell wall, composition, appendages, virulence factors, extracellular products, toxins, mechanisms of action of toxins)
    • processes, replication, and genetics (eg, asexual vs. sexual, metabolism, growth)
    • antifungal agents (eg, mechanisms of action on fungus, toxicity to humans, and mechanisms of resistance)
  • Parasites
  • Prions

Normal age-related findings and care of the well patient

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal Processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal Processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal Processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal Processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

Normal processes

Abnormal Processes: Health and Health Maintenance, Screening, Diagnosis, Management, Risks, Prognosis

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