• Clinical science

Measles (Rubeola)

Abstract

Measles (Rubeola) is a highly infectious disease that is caused by a paramyxovirus. There are two phases of disease: a catarrhal (prodromal) stage and an exanthem stage. The catarrhal stage is characterized by a fever with conjunctivitis, coryza, cough, and pathognomonic Koplik spots on the buccal mucosa. The sudden development of a high fever, malaise, and exanthem represents the next phase. The exanthem stage is typically characterized by an erythematous maculopapular rash that originates behind the ears and spreads to the rest of the body towards the feet. Infection is usually self-limiting and followed by lifelong immunity. Disease management includes vitamin A supplementation, symptomatic treatment, and possible post-exposure prophylaxis (PEP). Measles causes transient immunosuppression and may lead to serious complications such as encephalitis, otitis, or pneumonia. A rare but lethal late complication of measles is subacute sclerosing panencephalitis (SSPE), which may also affect immunocompetent individuals. Vaccination against measles (active immunization) is administered in association with the mumps and rubella (MMR) vaccine; the first dose is recommended between the ages of 12–15 months and the second dose between 4–6 years of age or at least 28 days after the first dose. The prognosis is good in uncomplicated cases; newborns and immunocompromised patients are more likely to suffer from severe complications.

Epidemiology

  • Distribution: Measles typically occurs in regions with low vaccination rates and in developing countries.
  • Peak incidence: < 12 months of age
  • Infectivity: ∼ 90%; highly contagious 5 days before and up to 4 days after the onset of exanthem.

References:[1][2]

Epidemiological data refers to the US, unless otherwise specified.

Etiology

References:[1]

Clinical features

Incubation period

  • Duration: ∼ 2 weeks after infection

Prodromal stage (catarrhal stage)

Exanthem stage

  • Duration: appears 1–2 days after enanthem and lasts ∼ 7 days
  • Presentation
    • High fever, malaise
    • Generalized lymphadenopathy
    • Erythematous maculopapular, blanching, partially confluent exanthem
      • Usually begin in the face, frequently behind the ears along the hairline
      • Disseminates to the rest of the body towards the feet (palm and sole involvement is rare)
      • Mild pruritus is possible

Recovery phase

  • The rash begins to fade after ∼ 5 days of onset; leaving a brown discoloration and desquamation in severely affected areas
  • The cough; may persist for another week and it may be the last remaining symptom.

References:[3][4][5][6]

Diagnostics

Measles should be suspected in a patient with typical clinical findings. Laboratory tests are always necessary to confirm the diagnosis.

References:[4][5][7]

Differential diagnoses

Differential diagnoses of pediatric rashes

Differential diagnoses of pediatric rashes Measles Scarlet fever Rubella Fifth disease (erythema infectiosum) Roseola infantum (exanthem subitum)

Chickenpox (Varicella)

Hand, foot, and mouth disease
Exanthem
  • Erythematous maculopapular, blanching, partially confluent exanthem
    • Usually begins on the face, frequently behind the ears → disseminates to the rest of the body (palms and soles typically spared)
    • Exanthem begins to fade after ∼5 days, with a brown discoloration and desquamation
  • Fine erythematous, maculopapular, blanching exanthem
    • Usually begins in the neck region; disseminates to the head, trunk, and extremities
    • Distinct appearance in the groin and bends of the joints
    • Pastia's lines
    • Brown discoloration and desquamation of the skin during the second to fourth week of infection
    • Early symptoms: sudden onset with high fever
  • Pink maculopapular, non-confluent exanthem
    • Begins at the head, primarily behind the ears → extends to the trunk and extremities
    • Transient; symptoms usually disappear within 3 days
  • Maculopapular, initially confluent exanthem → adopts a lace-like and reticular appearance over time
    • Initially typical red flushed appearance of the cheeks with perioral pallor; “slapped cheekappearance; spreads to extremities and trunk
    • Mild pruritus in 50% of cases
      • Becomes more pronounced after exposure to sunlight or heat
    • Exanthem fades after ∼5–8 days; may be recurrent for several months following the initial infection
  • Rose-pink maculopapular, patchy, blanching exanthem
    • Originates on the trunk; may spread to face and extremities
    • Develops as the fever subsides
    • Frequently observed from only several hours to a maximum of 3 days
  • Vesicular rash on an erythematous background; simultaneous occurrence of various stages of rash (starry sky appearance): papules, vesicles, crusted papules and hypopigmented healed lesions
    • Rash begins on the trunk, scalp, face and proximal limbs
    • Involve hands, feet and mucous membranes
    • Severe pruritus
    • Exanthem fades after ∼1 week
  • Tender macules and vesicular rash, especially affecting the feet and hands, and sometimes the buttocks and groin areas
    • Rarely generalized
    • Exanthem fades after ∼4 days
Other features
  • Exanthem stage (within 48 hours following disease onset)
    • Typical red flushed appearance of the cheeks with perioral pallor
    • Red tongue with papillary hyperplasia"strawberry tongue"
    • Tonsillopharyngitis
  • General health primarily unaffected; mild disease
  • Suboccipital and post-auricular lymphadenopathy
  • Forcheimer sign: pin-point enanthem of the soft palate
  • General health primarily unaffected (mild disease)
  • Arthritis
  • Prodrome possible but not typical (1–2 days prior to the onset of exanthem)
  • Associated oropharyngeal and urogenital ulcers
  • Poor general condition
  • Highly contagious
  • In most cases, begins with stomatitis and enanthem: involve the tongue, buccal mucosa and hard palate; the vesicles erode leaving behind an erythematous base
  • Fever
  • Almost always self‑limiting

As with all rashes, always consider drug reactions!

References:[8][9][10]

The differential diagnoses listed here are not exhaustive.

Treatment

References:[5][11][12]

Complications

Complications are likely to occur when the fever does not subside after a few days from the onset of the exanthem!

References:[13][1][4][5][14][15][16]

We list the most important complications. The selection is not exhaustive.

Prognosis

  • The prognosis of measles infection is good in uncomplicated cases.
  • Fatal courses are more likely in newborns and immunocompromised patients.
  • The fatality rate in developing countries is high due to secondary bacterial infections.

References:[5]

Prevention

Immunization

  • Vaccine: : live, attenuated virus; in combination with the mumps and rubella (MMR) vaccine and possibly varicella (MMRV) vaccine
  • Primary immunization
  • PEP
    • Indication: In negative or indeterminate serology
    • Active immunization ;:
      • Immunocompetent patients after direct exposure
    • Passive immunization
  • Further measures for individuals with contact
    • Persons with close contact to infected individuals should avoid communal facilities.
    • Not required for: immunization, postexposure prophylaxis, or following prior infection

Reporting regulations

Measles is a notifiable disease. Cases should be reported within 24 hours to the CDC or National Center for Immunization and Respiratory Diseases (NCIRD).

References:[1][7]