• Clinical science



Intussusception occurs when a proximal part of the bowel invaginates into a distal part, leading to a mechanical obstruction and bowel ischemia. Infants aged 3–12 months are most commonly affected, usually with no identifiable underlying cause. Some patients may have an intraperitoneal anomaly or abnormality which initiates the process of intussuception (pathological lead point). The patient is typically chubby and healthy-looking, and presents with acute cyclical abdominal pain, knees drawn to the chest, and vomiting (initially nonbilious). Pallor, lethargy, and altered mental status may be present. A late-onset symptom is “currant jelly" stool (stool with blood and mucus) passed from the ischemic bowel. A classic sign is a palpable right upper quadrant (RUQ) mass on abdominal examination, seen as a target or pseudokidney sign on abdominal ultrasound. Contrast enema, i.e., pneumatic insufflation or hydrostatic enema with normal saline or barium, is the best confirmatory diagnostic test, and often has therapeutic effects. Intussusception is considered a surgical emergency, as it may lead to bowel necrosis and perforation if left untreated. Open surgery is indicated when non-operative measures fail, a pathological lead point is suspected, or bowel perforation is present. If treated before complications arise, patients generally have an excellent prognosis.


  • Sex: > (3:2)
  • Peak incidence: 3–12 months; otherwise commonly occurs in children 5 months to 6 years of age
  • One of the most common causes of bowel obstruction in childhood


Epidemiological data refers to the US, unless otherwise specified.




  • Ileocecal invagination (most common; accounts for 85–90% of cases)
  • Ileoileal invagination
  • Ileocolic invagination
  • Colosigmoidal invagination
  • Appendicocecal invagination (very rare)



  • Imbalance in the bowel wall (idiopathic or via a pathological lead point) → a portion of intestinal bowel (intussusceptum) invaginates or “telescopes” into the distal adjacent bowel loop; (intussuscipiens) → impaired lymphatic drainage and increasing pressure in intussusceptum bowel wall → venous impairment → mesenteric vessels are congested ischemia of intussusceptum bowel wal; l → bowel mucosa sloughs off (most sensitive to bowel ischemia since it is the furthest from the arterial supply) transmural necrosis and perforation with prolonged ischemia
  • The dysfunctional passage leads to a mechanical bowel obstructionvomiting


Clinical features

  • Child typically looks healthy
  • Acute cyclical colicky abdominal pain (sudden screaming or crying spells), often with legs drawn up, with asymptomatic intervals
    • Acute attacks occur approx. every 15–30 min.
  • Vomiting (initially nonbilious)
  • Lethargy , pallor, and other symptoms of shock or altered mental status may be present.
  • Abdominal tenderness, palpable sausage-shaped mass in the RUQ , and an “emptiness” or retraction in the right lower quadrant (Dance sign) during palpation
  • High-pitched bowel sounds on auscultation
  • Currant jelly stool (usually a late sign) may be noticed in passed stool or during digital rectal examination [2][1]

Less than 15% of patients with intussusception present with the classic triad of abdominal pain, a palpable sausage-shaped abdominal mass, and blood per rectum!




  • If clinical suspicion is high : perform enema .
  • If the diagnosis is unclear at presentation or pathological lead points are suspected : perform radiographic imaging (ultrasound or abdominal x-ray) to confirm the diagnosis.



Differential diagnoses

Differential diagnosis of lower gastrointestinal bleeding in children
Age group Condition Findings
First month of life (neonate)
  • Visualized during clinical exam of perianal area
  • Abdominal x-ray: bird-beak sign
  • Upper gastrointestinal series: malpositioned ligament of Treitz
1 month to 1 year (infant)
  • Intussusception
  • Cow's milk protein-specific IgE
  • Visualized during clinical exam of perianal area
1 year to 2 years
  • Technetium-99m pertechnetate scintiscan: gastric mucosa
> 2 years
  • Juvenile polyps
  • Visualized during colonoscopy
  • Endoscopy and biopsy: inflamed mucosa extending from the rectum

Intussusception, alongside incarcerated hernia, is one of the most common causes of bowel obstruction in children! It is the most common cause of bowel obstruction in the first two years of life!

The differential diagnoses listed here are not exhaustive.


Urgent intervention is necessary for intussusception to prevent potentially life-threatening complications!



We list the most important complications. The selection is not exhaustive.


The prognosis of intussusception depends on how quickly it is treated. Most cases may be treated successfully with conservative pneumatic insufflation (air enema) or hydrostatic reduction. The absence of ischemia or necrotic bowel is associated with a good prognosis.

  • Success rates for reduction: 80–90%
  • Rate of relapse in patients with non-surgical reduction: ∼ 10–15%
  • 1. Irish MS. Pediatric Intussusception Surgery. In: Grewal H. Pediatric Intussusception Surgery. New York, NY: WebMD. http://emedicine.medscape.com/article/937730. Updated May 13, 2015. Accessed January 24, 2017.
  • 2. Kitagawa S, Miqdady M. Intussusception in children. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. https://www.uptodate.com/contents/intussusception-in-children?source=search_result&search=intussusception%20in%20children&selectedTitle=1~112. Last updated March 30, 2016. Accessed January 24, 2017.
  • 3. Ong NT, Beasley SW. The leadpoint in intussusception. J Pediatr Surg. 1990; 25(6): pp. 640–643. pmid: 2359000.
  • 4. Blanco FC. Intussusception. In: Cuffari C. Intussusception. New York, NY: WebMD. http://emedicine.medscape.com/article/930708. Updated March 3, 2016. Accessed January 24, 2017.
  • 5. Holmes M, Murphy V, Taylor M, Denham B. Intussusception in cystic fibrosis. Arch Dis Child. 1991; 66(6): pp. 726–727. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1793149/.
  • 6. Mandeville K, Chien M, Willyerd FA, Mandell G, Hostetler MA, Bulloch B. Intussusception: clinical presentations and imaging characteristics. Pediatr Emerg Care. 2012; 28(9): pp. 842–844. doi: 10.1097/PEC.0b013e318267a75e.
  • 7. West KW, Stephens B, Vane DW, Grosfeld J. Intussusception: current management in infants and children. Surgery. 1987; 102(4): pp. 704–710. pmid: 3660243.
  • 8. Hryhorczuk AL, Strouse PJ. Validation of US as a first-line diagnostic test for assessment of pediatric ileocolic intussusception. Pediatr Radiol. 2009; 39(10): pp. 1075–1079. doi: 10.1007/s00247-009-1353-z.
  • 9. Del-pozo G, Albillos JC, Tejedor D, et al. Intussusception in children: current concepts in diagnosis and enema reduction. Radiographics. 1999; 19(2): pp. 299–319. doi: 10.1148/radiographics.19.2.g99mr14299.
  • 10. Wolfram W. Pediatric Gastrointestinal Bleeding. In: Minkes RK. Pediatric Gastrointestinal Bleeding. New York, NY: WebMD. http://emedicine.medscape.com/article/1955984. Updated December 16, 2016. Accessed January 24, 2017.
  • 11. Bonnard A, Demarche M, Dimitriu C, et al. Indications for laparoscopy in the management of intussusception: A multicenter retrospective study conducted by the French Study Group for Pediatric Laparoscopy. J Pediatr Surg. 2008; 43(7): pp. 1249–1253. doi: 10.1016/j.jpedsurg.2007.11.022.
last updated 06/12/2020
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