Collection of dermatological disorders

Last updated: June 29, 2022

Summarytoggle arrow icon

References:[1][2][3]

[7][8]

Types of miliaria
Miliaria crystallina Miliaria rubra Miliaria profunda
Epidemiology
  • Most common type
  • Usually seen in adult men in tropical climates, who have had repeated episodes of miliaria rubra
Level of sweat duct blockage
Clinical features
  • Clear 1–2 mm vesicles with no erythema

  • Description: reticular erythema with telangiectasias
  • Etiology: paralysis of the deep vascular plexus of the skin caused due to chronic heat application (e.g., infrared radiation, hot water bottles)
  • Pathophysiology: direct skin application of heat for extended periods of time → direct heat triggers increased melanin production → marbled, brownish hyperpigmentation
  • Treatment [13]
  • Complications [13]

  • Callus: thick, toughened skin caused by repeated mechanical pressure and friction
  • Clavus: a painful, hyperkeratotic lesion with a center core (corn) caused by frictional forces and trauma

  • Description: chronic facial dermatitis affecting the perioral region
  • Epidemiology: primarily children and women 20–45 years of age [15]
  • Etiology
    • Unknown
    • Presumably caused by regular application of (glucocorticoid) creams and/or cosmetics
  • Clinical features
    • Erythema with grouped papules and pustules
    • Dry skin with painful burning and a sensation of tightness
    • No residual scarring after resolution
  • Treatment

Types of livedo reticularis [16]
Physiological livedo (idiopathic livedo) Pathological livedo (livedo racemosa)
Definition
  • A vascular syndrome that can be caused by either benign autonomic dysregulation of cutaneous perfusion or pathological obstruction of blood vessels
Epidemiology/etiology
Pathophysiology
  • Autonomic dysregulation (functional disturbance) causing slowed cutaneous perfusion in response to external factors (i.e., cold)
  • Localized obstructions slow the blood flow (organic disturbance)
Clinical features
  • Symmetrical livedo reticularis (regular, small, round) of the extremities and sometimes the trunk
  • Triggered by cold, regresses after application of warmth
Treatment
  • Warmth, sauna, alternating cold and warm baths
  • Treat the underlying disease
Prognosis
  • Improves with age
  • Depends on the underlying disease (usually more difficult to treat)

Livedo reticularis that does not regress after application of warmth is indicative of an underlying vascular disease and requires treatment.

  • Description: inflammatory skin reaction in response to short hair that becomes entrapped within the skin
  • Etiology
    • Usually occurs due to shaving (also known as razor bumps)
    • Most common in African American men because the hair shafts typically form tight coils
  • Pathophysiology
    • Extrafollicular penetration: Hair enters the interfollicular epidermis after it exits the follicular orifice.
    • Transfollicular penetration: Hair penetrates the dermis before exiting the follicular orifice.
  • Clinical features
  • Diagnostics: a clinical diagnosis
  • Treatment

  • Definition: a rare, very aggressive vascular malignancy, arising from endothelial cells of blood or lymphatic vessels [20]
  • Epidemiology: peak incidence age > 70 years [20]
  • Etiology [20]
  • Clinical features [21][22]
    • Location
      • More common in sun-exposed areas
      • Usually occur on the head, neck, and breast
      • May involve the internal organs (e.g., hepatic angiosarcoma)
    • Lesion
      • Blue/purple-colored with a bruise-like appearance
      • Later stage: hemorrhage or ulceration
      • High variability in appearance
  • Treatment [22]
    • Complete resection with wide margins
    • Resection may be complicated by the aggressive course of the disease and delayed diagnosis.

Cutaneous granulomas are a group of conditions characterized by a chronic inflammatory skin response to a variety of stimuli, including metabolites, foreign bodies, and infection. They are classified as infectious or noninfectious. Diagnosis is primarily clinical For more information on the etiology, pathophysiology, and pathology of these conditions, see “Granulomatous inflammation.” [30]

Noninfectious cutaneous granulomas

Noninfectious cutaneous granulomas are often manifestations of systemic diseases, including diabetes, rheumatoid arthritis, and sarcoidosis.

Granuloma annulare

Necrobiosis lipoidica [34]

Rheumatoid nodules

  • Definition: inflammatory cutaneous or subcutaneous lesions found primarily at pressure points (e.g., extensor side of the forearm, bony prominences)
  • Epidemiology [35]
  • Clinical features: nontender, firm, subcutaneous nodules
  • Histopathology: central necrosis with surrounding palisading histiocytes and granulomatous tissue [35]
  • Treatment: intralesional corticosteroid injection or excision only required if the nodule causes pain or impairs movement
  • For more information, see “Rheumatoid arthritis.”

Lupus pernio

Foreign body granulomas

Infectious cutaneous granulomas

  1. Singh V. General Anatomy. Elsevier Health Sciences ; 2015
  2. Cutaneous Cysts. https://www.msdmanuals.com/professional/dermatologic-disorders/benign-skin-tumors,-growths,-and-vascular-lesions/cutaneous-cysts. Updated: January 1, 2018. Accessed: April 27, 2018.
  3. Sangueza OP, Moradi S, Mansoori P, et al.. Dermatopathology Primer of Cutaneous Tumors. CRC Press ; 2015
  4. Opavsky MA. Cat scratch disease: The story continues.. The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses. 1997; 8 (1): p.43-9. doi: 10.1155/1997/982908 . | Open in Read by QxMD
  5. Berzigotti A, Magalotti D, Zappoli P, Rossi C, Callea F, Zoli M. Peliosis hepatis as an early histological finding in idiopathic portal hypertension: A case report.. World journal of gastroenterology. 2006; 12 (22): p.3612-5. doi: 10.3748/wjg.v12.i22.3612 . | Open in Read by QxMD
  6. Atila K, Coker A, Uçar D, et al. A rare clinical entity misdiagnosed as a tumor: peliosis hepatis.. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2007; 13 (2): p.149-53.
  7. Bleibel W, Curry MP. Peliosis Hepatis. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. https://www.uptodate.com/contents/peliosis-hepatis.Last updated: June 27, 2017. Accessed: September 14, 2017.
  8. Hepatic Peliosis. https://radiopaedia.org/articles/hepatic-peliosis. Updated: September 14, 2017. Accessed: September 14, 2017.
  9. Wenzel FG, Horn TD. Nonneoplastic disorders of the eccrine glands.. J Am Acad Dermatol. 1998; 38 (1): p.1-17; quiz 18-20. doi: 10.1016/s0190-9622(98)70532-8 . | Open in Read by QxMD
  10. Fernández-Crehuet P, Ruiz-Villaverde R. Pitted keratolysis: an infective cause of foot odour.. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2015; 187 (7): p.519. doi: 10.1503/cmaj.140809 . | Open in Read by QxMD
  11. Taïeb A, Plantin P, Du Pasquier P, Guillet G, Maleville J. Gianotti-Crosti syndrome: a study of 26 cases.. Br J Dermatol. 1986; 115 (1): p.49-59. doi: 10.1111/j.1365-2133.1986.tb06219.x . | Open in Read by QxMD
  12. Chuh A, Lee A, Zawar V. The diagnostic criteria of Gianotti-Crosti syndrome: are they applicable to children in India?. Pediatr Dermatol. undefined; 21 (5): p.542-7. doi: 10.1111/j.0736-8046.2004.21503.x . | Open in Read by QxMD
  13. Wiechers T, Rabenhorst A, Schick T, et al. Large maculopapular cutaneous lesions are associated with favorable outcome in childhood-onset mastocytosis.. J Allergy Clin Immunol. 2015; 136 (6): p.1581-1590.e3. doi: 10.1016/j.jaci.2015.05.034 . | Open in Read by QxMD
  14. Tolaymat L, Hall MR. Perioral Dermatitis. StatPearls. 2020 .
  15. Iacobelli J, Harvey NT, Wood BA. Sebaceous lesions of the skin. Pathology. 2017; 49 (7): p.688-697. doi: 10.1016/j.pathol.2017.08.012 . | Open in Read by QxMD
  16. Bryden AM, Dawe RS, Fleming C. Dermatoscopic features of benign sebaceous proliferation. Clin Exp Dermatol. 2004; 29 (6): p.676-677. doi: 10.1111/j.1365-2230.2004.1612.x . | Open in Read by QxMD
  17. Vlahova L, Kretschmer L, Schön MP, Mössner R. Embolia Cutis Medicamentosa after Subcutaneous Injection with Glatiramer Acetate. Case Reports in Dermatology. 2021; 13 (1): p.114-120. doi: 10.1159/000510017 . | Open in Read by QxMD
  18. Tabor D, Bertram CG, Williams AJK, Mathers ME, Biswas A. Nicolau Syndrome (Embolia Cutis Medicamentosa): A Rare and Poorly Recognized Iatrogenic Cause of Cutaneous Thrombotic Vasculopathy. Am J Dermatopathol. 2018; 40 (3): p.212-215. doi: 10.1097/dad.0000000000000972 . | Open in Read by QxMD
  19. Guarneri C, Bevelacqua V, Polimeni G. Embolia cutis medicamentosa (Nicolau syndrome). QJM. 2011; 105 (11): p.1127-1128. doi: 10.1093/qjmed/hcr194 . | Open in Read by QxMD
  20. Wilbrand J-F, Wilbrand M, Schaaf H, Howaldt H-P, Malik C-Y, Streckbein P. Embolia Cutis Medicamentosa (Nicolau Syndrome) after Endodontic Treatment: A Case Report. J Endod. 2011; 37 (6): p.875-877. doi: 10.1016/j.joen.2011.01.004 . | Open in Read by QxMD
  21. Bolognia J, Jorizzo J, Schaffer J. Dermatology: 2-Volume Set. Elsevier ; 2012
  22. Barbieri JS, Rodriguez O, Rosenbach M, Margolis D. Incidence and Prevalence of Granuloma Annulare in the United States. JAMA dermatology. 2021; 157 (7): p.824-830. doi: 10.1001/jamadermatol.2021.1847 . | Open in Read by QxMD
  23. Cyr PR. Diagnosis and management of granuloma annulare. Am Fam Physician. 2006; 74 (10): p.1729-34.
  24. Wang J, Khachemoune A. Granuloma Annulare: A Focused Review of Therapeutic Options. Am J Clin Dermatol. 2017; 19 (3): p.333-344. doi: 10.1007/s40257-017-0334-5 . | Open in Read by QxMD
  25. Tong LX, Penn L, Meehan SA, Kim RH. Necrobiosis lipoidica.. Dermatol Online J. 2018; 24 (12).
  26. Aróstegui Aguilar J, Diago A, Carrillo Gijón R, et al. Granulomas in Dermatopathology: Principal Diagnoses - Part 1. Actas Dermo-Sifiliográficas (English Edition). 2021; 112 (8): p.682-704. doi: 10.1016/j.adengl.2021.07.011 . | Open in Read by QxMD
  27. Young A, Koduri G. Extra-articular manifestations and complications of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007; 21 (5): p.907-927. doi: 10.1016/j.berh.2007.05.007 . | Open in Read by QxMD
  28. Hubail A, Belkharoeva R, Tepluk N, Belerosova T. Lupus pernio (Besnier-Tenneson syndrome): A rare form of sarcoidosis. Dermatology Reports. 2018; 10 (2). doi: 10.4081/dr.2018.7696 . | Open in Read by QxMD
  29. Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E. Cutaneous Granulomatosis: a Comprehensive Review. Clin Rev Allergy Immunol. 2018; 54 (1): p.131-146. doi: 10.1007/s12016-017-8666-8 . | Open in Read by QxMD
  30. Molina-Ruiz AM, Requena L. Foreign Body Granulomas. Dermatol Clin. 2015; 33 (3): p.497-523. doi: 10.1016/j.det.2015.03.014 . | Open in Read by QxMD
  31. Sajjan V, Swamy M, Lunge S, Pandit A. Livedo reticularis: A review of the literature. Indian Dermatology Online Journal. 2015; 6 (5): p.315-321. doi: 10.4103/2229-5178.164493 . | Open in Read by QxMD
  32. Xeroderma pigmentosum. https://rarediseases.org/rare-diseases/xeroderma-pigmentosum/. . Accessed: December 17, 2020.
  33. Lucero R, Horowitz D. Xeroderma Pigmentosum. StatPearls. 2020 .
  34. Black JO. Xeroderma Pigmentosum. Head and Neck Pathology. 2016; 10 (2): p.139-144. doi: 10.1007/s12105-016-0707-8 . | Open in Read by QxMD
  35. Angiosarcoma - National Cancer Institute. https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-vascular-tumors/angiosarcoma. Updated: February 27, 2019. Accessed: April 6, 2020.
  36. Gaballah AH, Jensen CT, Palmquist S, et al. Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol. 2017; 90 (1075): p.20170039. doi: 10.1259/bjr.20170039 . | Open in Read by QxMD
  37. Tambe SA, Nayak CS. Metastatic Angiosarcoma of Lower Extremity.. Indian dermatology online journal. undefined; 9 (3): p.177-181. doi: 10.4103/idoj.IDOJ_92_17 . | Open in Read by QxMD
  38. Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res. 2016; 308 (10): p.743-749. doi: 10.1007/s00403-016-1697-9 . | Open in Read by QxMD
  39. Kettelhut EA, Traylor J, Roach JP. Erythema Ab Igne. StatPearls. 2020 .

3 free articles remaining

You have 3 free member-only articles left this month. Sign up and get unlimited access.
 Evidence-based content, created and peer-reviewed by physicians. Read the disclaimer