• Clinical science

Pneumocystis pneumonia

Summary

Pneumocystis jirovecii pneumonia (PCP), previously known as Pneumocystis carinii pneumonia, is an opportunistic fungal lung infection occurring almost exclusively in immunocompromised individuals. In 50% of cases, PCP is the first manifestation of AIDS (acquired immune deficiency syndrome), but it may be caused by other immunodeficiency disorders. PCP should be suspected in patients with a history of progressive dyspnea and a dry cough with resistance to standard antibiotic treatment. Signs that support this diagnosis include a CD4 count < 200/μL, an increased beta-D-glucan level, and diffuse bilateral infiltrates on chest x-ray. Management of PCP includes high-dose trimethoprim/sulfamethoxazole (TMP/SMX), treatment of the underlying immunodeficiency disorder, and steroids in the case of severe respiratory insufficiency.

Definition

References:[1]

Etiology

References:[2][3][4][5]

Clinical features

  • Symptoms typically have a gradual onset (days to weeks) and include:
    • Low-grade fever and malaise
    • Dyspnea and non-productive cough
    • Fatigue, weight loss, chills
  • May progress to fulminant respiratory failure
  • Can be asymptomatic

References:[6]

Diagnostics

If PCP is suspected; based on the history and clinical examination, oxygen saturation, the CD4+ count, the beta-D-glucan level should be measured and a CXR conducted; . If the CXR is inconclusive, a high-resolution CT scan can be obtained; . The diagnosis should generally be confirmed via microscopic identification of P. jirovecii from respiratory secretions.

Clinical examination

PCP is often misdiagnosed as atypical pneumonia or bronchitis because of the persistent cough and similar auscultatory findings.

Laboratory tests

  • CD4 count: typically < 200/μL
  • ↑ Beta‑D‑glucan
  • Confirmatory test: microscopic identification of P. jirovecii in specimen obtained via bronchoalveolar lavage or induced sputum, with methenamine silver staining and immunofluorescence
    • Staining enables visualization of disc-shaped P. jirovecii cysts with central spores

Imaging

  • Chest X‑ray
    • Typically symmetrical, diffuse interstitial infiltrates extending from the perihilar region
    • May sometimes be normal
  • High-resolution CT
    • Indicated if PCP is still suspected in a patient with a normal CXR
    • High sensitivity for PCP; a negative scan thus suggests the diagnosis of PCP is unlikely

References:[7][8][2][6][9][10][11]

Treatment

Acute Infection

If a patient with suspected PCP is acutely ill then empiric treatment should be started without delay!

PCP prophylaxis

  • Indication
    • Primary prophylaxis: CD4‑cell count below 200/μl (e.g., AIDS, bone marrow suppression due to cytotoxic therapy, or primary immunosuppressive disorders)
    • Secondary prophylaxis: to prevent recurrence in patients with AIDS or other immunocompromising conditions
  • Implementation

References:[12][13][14][15]

Complications

We list the most important complications. The selection is not exhaustive.

Prognosis

  • PCP was formerly the most common cause of death in HIV‑positive patients during the early years of the HIV epidemic.
    • The introduction of HAART (highly active antiretroviral therapy) and TMP/SMX prophylaxis in patients with a CD4 count < 200/μl has significantly improved the long-term outcome of the disease.
    • Despite adequate prophylaxis, PCP infection may lead to death in patients presenting with severe symptoms (e.g., respiratory failure).

References:[5]