- Clinical science
Acute otitis media (AOM) is a viral or bacterial infection of the middle ear that is most commonly caused by Streptococcus pneumoniae. AOM is a common infection in children under the age of five years and it usually follows an upper respiratory tract (URT) infection. It is characterized by an acute onset of symptoms (e.g., otalgia, fever, anorexia) with signs of middle ear inflammation (e.g., bulging tympanic membrane, effusion). Mild unilateral infections can be managed without antibiotics, as they are often self-limiting. Bilateral AOM or severe symptoms are usually treated with oral amoxicillin. Tympanostomy and insertions of tympanostomy tubes is recommended in children with recurrent AOM. Complications are rare and occur mostly in immunosuppressed patients or in AOM due to highly virulent, drug-resistant bacteria. The most common complication is acute mastoiditis, but facial palsy, labyrinthitis, and in rare cases, even intracranial abscesses may also occur.
Highest incidence between 6–24 months of age
- ∼ 70% of children < 2 years old experience AOM at least once
- Slightly higher incidence in boys
- Immunization of infants against pneumococci has decreased the incidence of AOM
Epidemiological data refers to the US, unless otherwise specified.
- Bacterial superinfection following a viral URT infection (95% of cases)
Risk Factors for AOM
- Bottle feeding/formula feeding, inadequate breastfeeding
- Pacifier use
- Passive cigarette smoke
- Children who attend day care centers
- Poor socioeconomic status
- The eustachian tube (ET) connects the middle ear with the nasopharynx and is lined with cilia, which drain the middle ear secretions into the nasopharynx.
- Obstruction/blockage of the ET → lack of ventilation and drainage of the middle ear →
Predisposing factors for ET obstruction
Inflammation of the ET mucosa
- Viral URT infection (most common cause)
- Allergic rhinitis
- Mechanical obstruction of the ET
- Infants: the ET of infants is shorter, narrower, and more horizontal → nasopharyngeal secretions easily reflux into the ET → more prone to developing AOM
- Inflammation of the ET mucosa
- In infants
- In older children
Otoscopy: tympanic membrane (TM) evaluation
- Early findings
- Retracted and hypomobile
- Loss of light reflex
- Late findings
- Early findings
- Tuning fork test: conductive hearing loss
- Symptomatic pain management (paracetamol, ibuprofen)
Antibiotics: not always indicated
First line: oral amoxicillin
- Add clavulanic acid if no improvement after 48 hours
- Alternative for patients with penicillin allergy
- Tympanocentesis; : Aspiration of contents of middle ear using a sterile needle, indicated in patients who do not respond to initial therapy (allows for culture of bacteria contained in middle ear fluid)
- Myringotomy: Incision in the TM to drain pus, indicated in patients with severe otalgia and bulging TM
- Myringotomy with tympanostomy: Incision in the TM and insertion of small tubes into the TM to allow air to enter the middle ear and fluid to drain, indicated in children with recurrent AOM
Ear drops are not effective in the treatment of otitis media and not every case of otitis media should be treated with antibiotics!
Complications are rare and are usually only seen in the following cases:
- Highly virulent bacteria (Group A ß-hemolytic streptococci).
- Immunocompromised host
- Inadequate dose/duration of antibiotics
- Bacterial drug resistance
- Definition: inflammation of the mastoid air cells
- Epidemiology: often occurs in children < 5 years
- Pathophysiology: infection spreads from the middle ear cavity into the mastoid, which is a closed bony compartment → collection of pus under tension and hyperemic resorption of the bony walls → destruction of the air cells (coalescent mastoiditis) → mastoid becomes a pus-filled cavity (empyema mastoid)
- Persistence/recurrence of otalgia and fever after initial improvement
- Ear discharge becomes profuse (discharge persisting > 3 weeks suggests mastoiditis).
- Tender and edematous mastoid
- Ear displaced laterally and forward
- In advanced stages, the retroauricular sulcus is obliterated and the ear can be pushed forward.
- Otoscopy: The TM may be perforated.
- First test: CT scan of the temporal bone
X-ray of the mastoid
- Early stage: The air cells appear cloudy and indistinct.
- Advanced stage: A cavity can be seen in the mastoid.
- Antibiotic treatment is always indicated
- Tympanostomy (myringotomy) + tympanostomy tube insertion: for early stages of mastoiditis
- Mastoidectomy; : is indicated in severe cases that do not improve with antibiotics + tympanostomy.
- Etiology: Inflammation spreads to the inner ear (labyrinth) through the round window.
- Severe vertigo, nausea, and vomiting
- Hearing loss
- Nystagmus towards healthy ear for weeks to months
- Change of lateralization in Weber's test
- Audiometry: sensorineural hearing loss
- Route of spread: direct spread of infection from the middle ear through the destroyed bone overlying the dura or through an emissary vein
- Clinical features
- Diagnostics: MRI/contrast-enhanced CT
- Treatment: IV antibiotics + drainage + mastoidectomy
We list the most important complications. The selection is not exhaustive.