Ascites is the abnormal accumulation of fluid within the peritoneal cavity and is a common complication of portal hypertension (e.g., due to liver cirrhosis, acute liver failure) and/or hypoalbuminemia (e.g., due to nephrotic syndrome). Other conditions resulting in ascites include chronic heart failure, inflammation of abdominal viscera (e.g., pancreatitis), and malignancies. Clinical features include progressive abdominal distention, shifting dullness, and a positive fluid wave test. Abdominal pain may be present in ascites due to acute inflammation. Diagnostics are aimed at identifying the underlying etiology and determining whether the ascitic fluid is infected. They include imaging (e.g., with abdominal ultrasound or CT abdomen and pelvis), which is used to identify free intraperitoneal fluid and possibly the underlying cause, and diagnostic paracentesis with . The (SAAG), or the difference between albumin levels in serum and ascitic fluid, is essential to determine the underlying cause. A indicates that the ascites is secondary to portal hypertension. An ascitic fluid neutrophil count ≥ 250 cells/mm3 indicates spontaneous bacterial peritonitis (SBP), which should be urgently managed with empiric antibiotic therapy. Management of ascites involves identifying and managing the underlying cause as well as dietary sodium restriction and diuretic therapy. Additionally, tense ascites and refractory ascites require therapeutic paracentesis. Liver transplant is a treatment option for patients with cirrhosis who develop ascites. Transjugular intrahepatic portosystemic shunts (TIPS) and peritoneovenous shunts are advanced treatment options for refractory ascites, which carries a high risk of mortality.
- The etiology can be determined using the serum-ascites albumin gradient (SAAG) based on Starling's law.
- SAAG = (albumin levels in serum) - (albumin levels in ascitic fluid)
High SAAG ascites
≥ 1.1 g/dL (obsolete term: transudate)
Low SAAG ascites
< 1.1 g/dL (obsolete term: exudate)
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Remember, exudative ascitic fluid is high in protein, like eggs.
- Progressive abdominal distention ; symptoms associated with increased abdominal distention include
- Fluid wave test: wave produced by tapping one side of the abdomen in a patient in supine position; this wave will be transmitted to the other side via ascitic fluid.
- Shifting dullness: change of resonance from dull to tympanic resonance when patient changes from supine to lateral decubitus position.
- Flank dullness: typically elicited only if > 1.5 L of ascitic fluid is present 
- Abdominal pain may be present
- Abdominal wall hernias (e.g., umbilical, inguinal, or incisional hernias)
- Peripheral or generalized edema
- Signs of underlying disease
Subtypes and variants
- Definition: collection of lymph in the abdominal cavity, which is characteristically triglyceride-rich and has a milky appearance
- Etiology: : malignancy (e.g., lymphoma), hepatic cirrhosis, or other lymph disorders (e.g., lymphatic hyperplasia) which result in increased lymph production
Diagnostics are used to confirm the presence of ascites, assess its severity, determine the underlying etiology, and evaluate for complications. 
Abdominal ultrasound with Doppler (initial study of choice)
- Free intraperitoneal fluid
- Features of underlying etiology (e.g., liver cirrhosis, hepatocellular carcinoma, Budd-Chiari syndrome, portal vein thrombosis, ovarian tumors; see respective articles for details)
CT abdomen and pelvis 
- Indications: to work up for the underlying cause as needed; examples include 
- Free intraperitoneal fluid
- Fluid density depends on the type of ascites
- CBC: abnormalities related to an underlying condition
- Coagulation panel: Thrombocytopenia and coagulopathy are signs of advanced liver disease.
- Liver chemistries
- Additional evaluation for the underlying condition: E.g., see “ .”
For further information on this procedure, see “Paracentesis.”
- All patients with new-onset ascites (to identify the underlying etiology) 
- To detect (SBP) or other peritoneal infections in the following situations:
Ascitic fluid analysis 
- Gross appearance: can provide supportive evidence of the underlying cause or complications
- Cell count and differential: A neutrophil count ≥ 250 cells/mm3 indicates spontaneous bacterial peritonitis.
- Ascitic fluid albumin: for SAAG calculation (obtain same-day serum and ascitic fluid samples) 
- Ascitic fluid total protein
|Differential diagnoses of ascites based on SAAG and ascitic fluid total protein |
|Ascites due to portal hypertension||Ascites due to other causes|
|SAAG|| || |
Ascitic fluid total protein levels
Additional studies (based on the pretest probability of the underlying etiology)
- Microbiology: ascitic fluid culture; in blood culture bottles (aerobic and anaerobic) and Gram stain 
- Studies to differentiate SBP from secondary spontaneous peritonitis: LDH, glucose, CEA, alkaline phosphatase (see “Spontaneous bacterial peritonitis” for details)
- Acid-fast bacilli smear and mycobacterial cultures (low sensitivity): only if there is clinical suspicion or a high risk of tuberculous peritonitis
Suspected malignancy (e.g., peritoneal carcinomatosis)
- Ascitic fluid cytology
- Ascitic fluid tumor markers: not routinely recommended for the assessment of malignancy-related ascites
- Suspected chylous ascites (milky ascitic fluid): Ascitic fluid triglyceride levels; levels > 200 mg/dL indicate chylous ascites 
- Suspected pancreatic ascites or bowel perforation: Ascitic fluid amylase levels; elevated levels provide supportive evidence of pancreatitis or bowel perforation 
The International Ascites Club classifies the severity classification of ascites as follows: 
- Mild ascites (grade 1): ascites only detectable by ultrasound
- Moderate ascites (grade 2): moderate abdominal distention
- Large ascites (grade 3): marked abdominal distention
- All patients
- Patients with cirrhotic ascites
- Patients with noncirrhotic ascites: treatment of the underlying cause, e.g.
Obtain hepatology consult for patients with new-onset ascites and known or suspected liver disease.
Medical and supportive therapy 
This section details the management of ascites due to cirrhosis. Medical and/or supportive management of other causes of ascites (e.g., heart failure, nephrotic syndrome, peritoneal carcinomatosis, tuberculosis) are outlined in the respective articles for these conditions.
Salt and fluid restriction
Dietary sodium restriction: 2 g/day or 88 mEq/d (2 g of sodium = 5 g of salt)
- Recommended for all patients
- Advise patients to restrict the amount of salt in home-cooked meals and to avoid precooked and prepackaged food.
- Consider referral to a nutritionist for counseling.
- Fluid restriction: 1 L/day (only if serum Na+ < 125 mEq/L)
- Monotherapy with spironolactone may be preferable for new-onset ascites, , , and outpatients.
- Combination therapy with spironolactone; PLUS furosemide in a 10:4 ratio may be preferable for recurrent or when faster resolution of ascites is required (e.g., in hospitalized patients).
- Once ascites is under control, taper to the minimum effective dose to reduce side effects.
Empiric antibiotic therapy 
- Patients with GI bleed due to cirrhosis: ceftriaxone until bleeding resolves and vasopressors are discontinued, for a maximum of 7 days
- SBP: See “ ” and “ .”
- Monitor weight, blood pressure, nutritional status, serum electrolytes, and renal function.
- Goals of diuretic therapy
- Discontinue or adjust the dosage of diuretics if adverse effects develop (e.g., hyponatremia, hyperkalemia, renal dysfunction).
Therapeutic paracentesis 
- Complications 
- Perform under ultrasound guidance to minimize complications. 
- A predetermined limit to the removed volume is usually not necessary. 
- Albumin replacement
Clotting factors (e.g., fresh frozen plasma) and/or platelets are not routinely recommended before paracentesis in patients with INR > 1.5 or platelets < 50 cells/mm3, as procedure-related hemorrhage is uncommon. 
Management of refractory ascites 
Ascites is considered refractory if it does not respond to treatment or recurs after therapeutic paracentesis despite dietary sodium restriction and high-dose diuretic therapy. The following recommendations apply to refractory ascites in patients with cirrhosis.
- Rule out transient refractoriness to diuretic therapy.
- Optimize medications and ensure adherence to a low-sodium diet.
- Patients who are on beta blockers:
- Consider or a on a case-by-case basis. 
- Consider discontinuing diuretic therapy if urine Na+ excretion is < 30 mEq/d. 
- Repeat large-volume paracentesis (with IV albumin).
- Evaluate for invasive management options in consultation with specialists.
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