- Clinical science
Leptospirosis is a zoonotic disease caused by gram-negative Leptospira bacteria. Direct transmission to humans occurs when broken skin and mucous membranes come into contact with the urine of infected animals such as rodents. The early phase of the disease is mild and characterized by non-specific symptoms (e.g., fever, headache, and myalgia). In most cases, symptoms resolve spontaneously after a week. However, in 10% of cases, the disease progresses rapidly to a severe form (icterohemorrhagic leptospirosis, or Weil disease), which typically presents with a triad of jaundice, bleeding manifestations, and acute kidney injury. Diagnosis is based on patient history, clinical findings, and laboratory tests. Treatment consists of antibiotics and supportive care.
- Pathogen: Leptospira; (especially L. interrogans; ) is a genus of gram-negative spirochete bacteria.
- Route of infection
The incubation time is 2–30 days. The disease has a mild form, which is characterized by non-specific symptoms that generally resolve spontaneously after a week. In 10% of cases, the disease progresses rapidly to a severe form (icterohemorrhagic leptospirosis, or Weil disease).
Mild (anicteric) leptospirosis
- Clinical manifestations during the early phase are due to bacteremia
Most cases of mild leptospirosis resolve spontaneously. Only 10% of patients with mild leptospirosis progress to the severe form (Weil's disease). 
Severe leptospirosis (Weil disease, icterohemorrhagic leptospirosis)
- Clinical features are due to systemic spread and multiorgan involvement
Severe leptospirosis is associated with a high mortality rate!
- For mild leptospirosis: aminopenicillins (ampicillin, amoxicillin), doxycycline
- For severe leptospirosis
If leptospirosis is suspected based on a patient's clinical features and history, empiric therapy should be started right away!