• Clinical science

Erythema nodosum


Erythema nodosum (EN) is an inflammation of subcutaneous fat caused by a delayed hypersensitivity reaction. Women in early adulthood are commonly affected. Most cases are idiopathic, but an association with a variety of diseases, including infections and autoimmune disorders (e.g., ulcerative colitis), is possible. The characteristic lesions are painful nodules on the lower legs (particularly shins). EN is a clinical diagnosis. The condition typically heals spontaneously within a few weeks and, therefore, generally requires no more treatment than supportive care (e.g., analgesia).


  • Sex: >
  • Peak incidence: 18–34 years


Epidemiological data refers to the US, unless otherwise specified.





Clinical features

  • Nonspecific symptoms: : fever, arthralgia , malaise, hilar lymphadenopathy
  • Painful, subcutaneous nodules on both pretibial (anterior leg) surfaces (less common on other areas of skin)
    1. Firm, erythematous (1st week)
    2. Fluctuant (without suppuration) and bluish (2nd week)
    3. Progressively fades (i.e., yellow or brown hue)





  • Symptomatic treatment
  • Treat underlying disease
  • In severe or refractory cases: systemic steroids



  • Usually self-limiting (within 2–8 weeks), or resolves earlier with effective treatment of underlying disease
  • Recurrence following discontinued treatment is common


  • 1. Hebel JL, James WD. Erythema Nodosum . In: Erythema Nodosum . New York, NY: WebMD. http://emedicine.medscape.com/article/1081633-overview. Updated March 3, 2016. Accessed June 7, 2017.
  • 2. Kroshinsky D, Callen J, Ofori AO, Romain PL. Erythema Nodosum. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. https://www.uptodate.com/contents/erythema-nodosum. Last updated November 30, 2016. Accessed June 23, 2017.
  • 3. Paller AS, Mancini AJ. Hurwitz Clinical Pediatric Dermatology. Elsevier Health Sciences; 2015.
  • 4. Gupta M, Singh K, Lehl SS, Bhalla M. Recurrent erythema nodosum: a red flag sign of hidden systemic vasculitis. BMJ Case Rep. 2013. doi: 10.1136/bcr-2013-009507.
  • Herold G. Internal Medicine. Cologne, Germany: Herold G; 2014.
last updated 09/09/2020
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