Parkinson disease

Parkinson disease (PD) is a neurodegenerative disease involving a progressive depletion of dopaminergic neurons in the basal ganglia, particularly the substantia nigra. PD usually manifests at approximately 60 years of age. Although PD is considered an idiopathic disease, genetic factors seem to play a role in about 10–15% of cases and, accordingly, familial clustering has been observed. The typical clinical picture seen in PD is called parkinsonism and features the classical cardinal symptom of bradykinesia along with resting tremor and/or rigidity. Postural instability is another frequent finding. While PD is the main cause, parkinsonism may also result from other factors, e.g., medication (secondary parkinsonism). Atypical parkinsonism may appear similar to PD, but often features additional or atypical symptoms. To date, there is no cure for PD. Symptomatic treatment includes physical therapy and, depending on patient age and individual symptoms, various medications (e.g., levodopa, dopamine agonists). In specific cases, deep brain stimulation (DBS) surgery may be beneficial.

• Parkinsonism
  • Parkinsonism is a syndrome featuring bradykinesia and either resting tremor or rigidity (or both).
  • However, research suggests that a constellation of resting tremor, asymmetric movement disorders, and responsiveness to levodopa treatment correlates better with PD-specific neuropathological changes than classic parkinsonism.
  • Secondary parkinsonism: parkinsonism with secondary causes such as medication, intoxication, and head trauma
  • Atypical parkinsonism: parkinsonism that occurs as a feature of neurodegenerative diseases other than Parkinson disease; , usually due to different or more extensive neuropathological changes and featuring additional or uncommon symptoms (e.g., early-onset postural instability). Disorders featuring atypical parkinsonism are termed Parkinson-plus syndromes.
• Parkinson disease: parkinsonism for which no cause can be determined (idiopathic)

References:^[1][2]

• Parkinson disease: PD is commonly considered idiopathic, although several etiologic factors (e.g., genetic predisposition) are being investigated.
• Secondary parkinsonism (pseudoparkinsonism)
  • Medication (drug-induced parkinsonism or “pseudoparkinsonism”)
    • Most frequent cause of secondary parkinsonism
    • Frequently used drugs with considerable anti-dopaminergic effects: typical antipsychotics (e.g., haloperidol), some antiemetics (e.g., metoclopramide), some calcium channel blockers (e.g., flunarizine, amiodarone), valproate, and lithium
    • MPTP: Illegal drug, metabolized to MPP+, damages substantia nigra
  • Metabolic disorders: e.g., Wilson disease
  • Toxins: e.g., manganese, carbon monoxide, carbon disulfide
  • Cerebrovascular disease (vascular parkinsonism): e.g., subcortical arteriosclerotic encephalopathy
  • CNS infections:
    • Viruses: e.g., herpes simplex virus, human immunodeficiency virus
    • Bacteria: e.g., Treponema pallidum
    • Protozoa: e.g., Toxoplasma gondii
    • Prion agents: e.g., Creutzfeldt-Jakob disease
• Atypical parkinsonism: depends on the underlying disease (e.g., genetic abnormalities in Huntington disease)

References:^[1][8]

• Earlier disease onset type: onset < 55 years
• Tremor dominant type: onset ≥ 55 years with tremor as sole initial (or generally predominating) symptom
• Non-tremor dominant type: onset ≥ 55 years with predominating bradykinesia/rigidity
• Rapid disease progression without dementia type: rapid progression of motor symptoms and death within 10 years

Older age, rigidity, and/or bradykinesia at onset signify a comparatively worse prognosis; tremor is a good prognostic sign!

References:^[9][10]

• Progressive dopaminergic neuron degeneration in the substantia nigra (part of the basal ganglia) and the locus coeruleus → dopamine deficiency at the respective receptors of the striatum with interrupted transmission to the thalamus and motor cortex → motor symptoms of PD.
• Serotonin and noradrenaline depletion (in the Raphe nuclei): likely cause of depressive symptoms
• Acetylcholine surplus (in the nucleus basalis of Meynert): likely cause of dyskinesia
• A further pathological hallmark of PD is the appearance of Lewy bodies
  • Aggregates of misfolded α-synuclein and other proteins (hyaline eosinophilic globules)
  • Seen in Lewy body dementia

References:^[11][1][3]

General

• Clinical course > 10 years; unilateral onset with persistently asymmetrical course (i.e. unilaterally pronounced symptoms) but may progress to the contralateral side
• Parkinsonism
  • Bradykinesia/akinesia
    • Slowness of movement in combination with decreased amplitude or speed during a sequence of movement
    • Bradydiadochokinesia
  • Resting tremor (4–6 Hz)
    • Pill-rolling tremor that subsides with voluntary movements, but increases with stress
    • Typical in hands; may involve the legs, jaw, lips, and tongue
  • Rigidity
    • Increased and persistent resistance to passive joint movement that is independent of speed of movement
    • Froment maneuver
      • The patient is asked to perform repetitive movements in the contralateral extremity (e.g., opening and closing of the left fist if the right side is examined) → Subclinical rigidity becomes more pronounced and may be detected.
    • Special form: cogwheel rigidity
• Postural instability
  • Imbalance and tendency to fall
  • Pull test
• Parkinsonian gait: shuffling gait with quickened and shortened steps
• Unhabituated glabellar reflex
• Signs of dystonia
• Pyramidal signs (but normal tendon reflexes)
• Good response to levodopa

TRAP – Tremor, Rigidity, Akinesia, and Postural instability

Other clinical features

• Early
  • Prodromal PD and/or Lewy body dementia: rapid eye movement sleep behavior disorder (RBD)
  • Sensory
    • Hyposmia or anosmia; (potential early symptom )
    • Dysesthesias: muscle and joint pain (often in the shoulder/arm region)
  • Motor: reduced swinging of arms while walking
  • Personality changes: e.g., withdrawal, apathy
• Late
  • Motor
    • Freezing : sudden inability to start or continue movements (e.g., while walking)
    • Propulsion: forward-leaning gait with risk of patient falling forward
    • Micrographia: size of handwriting is reduced
    • Low degree of facial expression (hypomimia), decreased blinking
  • Autonomic
  • Depression, dementia

Parkinsonism is required for the diagnosis of Parkinson disease! Unilateral onset is characteristic of Parkinson disease!

References:^{[12][13][1][14][15][16][17]}

Parkinson disease is a clinical diagnosis!

Pharmacological

Levodopa challenge test: (alternatively apomorphine test): The result is positive if administration of levodopa/apomorphine relieves symptoms.

Imaging

Imaging is not routinely required for diagnosis, but should be considered in an atypical presentation or to rule out other underlying disorders.

• MRI:
  • Conventional MRI is usually used to rule out other possible causes of parkinsonism (e.g., strokes, tumors)
  • Advanced MRI techniques (e.g., diffusion-weighted imaging) allow PD to be distinguished from atypical parkinsonian syndromes in some cases.

References:^{[14][18][19][20]}

Differential diagnosis of parkinsonism
	Parkinson disease (PD)	Secondary parkinsonism	Parkinson-plus syndromes
Etiology	Idiopathic Various factors (genetic, environmental, inflammation, immune response, oxidative stress) appear to play a role.	Drug-induced (e.g., haloperidol) Toxin-induced (e.g., exposure to manganese) Metabolic (e.g., Wilson disease) Structural (e.g., vascular disorders) Normal pressure hydrocephalus (NPH) Infections (e.g., HIV)	Multiple system atrophy (MSA) Dementia with Lewy-bodies (DLB) Corticobasal degeneration (CBS) Progressive supranuclear palsy (PSP)
Pathophysiology	Degeneration of dopaminergic neurons chiefly in the substantia nigra → dopamine deficiency in the striatum → reduced excitatory input to the motor cortex → bradykinesia Serotonin, norepinephrine, and acetylcholine metabolism are also affected → depression, dementia Depigmentation, atrophy, gliosis Lewy bodies	Variable, depends on the cause	MSA Secondary neuronal degeneration as a result of Lewy body deposition in glial cells (and subsequent glial and myelin dysfunction) Particularly in the putamen, the pons, and the cerebellum DLB Cerebral atrophy due to deposition of Lewy bodies, amyloid plaques, and neurofibrillary tangles in neurons Occurs in cortical layers throughout the brain; the frontal and temporal lobes are particularly affected. CBS: asymmetric frontoparietal atrophy and gliosis PSP: neuronal loss and gliosis particularly of the basal ganglia, midline thalamic nuclei and the brainstem
Clinical features	Parkinsonism: bradykinesia plus either resting tremor or rigidity (or both) Postural instability Parkinsonian (shuffling) gait Course: Unilateral onset Progression usually over > 10 years	Parkinsonism: bradykinesia plus either resting tremor or rigidity (or both) Course: variable, depends on the cause	Atypical parkinsonism: Generally poor response to levodopa Dementia, oculomotor dysfunction, and early onset of autononomic dysfunction and gait instability are common. Particular syndromes show further characteristic symptoms. Course: The progression is usually faster and the prognosis is usually worse than in PD.
Additional diagnostic tests	Parkinson disease is a clinical diagnosis (MDS criteria)! Levodopa challenge test: Symptoms usually improve with levodopa administration. Imaging to rule out other causes MRI DaTSCAN IBZM-SPECT	To confirm specific etiologies: Laboratory: drugs, toxins, infections, metabolic disorders Imaging: NPH, vascular disorders, tumors	May be distinguished from PD with the help of the clinical picture or via the levodopa challenge test and/or imaging studies (see the additional diagnostic tests for PD on the left). Distinction from Alzheimer disease MSA: dementia is possible, but not common DLB: frequent visual hallucinations CBS: cortical atrophy more pronounced in supplementary motor area and superior frontal gyrus PSP: dementia usually only in later stages

References:^[1][21]

The differential diagnoses listed here are not exhaustive.

To date, there is no cure for PD. Treatment is aimed at relieving symptoms and should generally begin once patients develop significant functional disability (see Parkinson disease medication).

General measures

• Physiotherapy
• Speech and language therapy
• Occupational therapy
• Support groups

Medical therapy

For details on effects, administration, and side effects, see medication for Parkinson disease.

• Levodopa is the drug of choice for the symptomatic therapy of Parkinson disease.
  • Dopaminergic therapy should be considered at an early stage if motor symptoms begin to substantially affect a patient's activities of daily living. The age of 65 should be considered a general point of reference rather than a fixed limit for beginning levodopa therapy.
  • In the early phase; of levodopa treatment, patients may experience a "honeymoon period" with relief of symptoms.
  • “On” (parkinsonism is relieved by the levodopa) and “off” (levodopa effect wears off, parkinsonism returns) episodes are another common phenomenon.
• Dopamine agonist in patients under the age of 65

Overstimulation of D2-receptors by levodopa or dopamine agonists may induce psychosis and hallucinations, especially in elderly patients with concurrent dementia or other psychiatric disorders!

Patients under the age of 65 with no significant comorbidities

• First-line treatment
  • Non-ergot dopamine agonists (e.g., pramipexole, ropinirole, apomorphine): as monotherapy or in combination with levodopa/carbidopa
  • MAO-B inhibitors (e.g., selegiline): may be used as a monotherapy or in combination with dopamine agonists or levodopa/carbidopa
  • COMT inhibitors (e.g., entacapone): in combination with levodopa/carbidopa
• Alternatives
  • Levodopa
    • Normally combined with a peripheral decarboxylase inhibitor like carbidopa
    • Most effective symptomatic treatment but carries a higher risk of dyskinesias than other medications
  • Ergot dopamine agonists (e.g., bromocriptine)
  • NMDA antagonists (e.g., amantadine): used to reduce levodopa-induced dyskinesias
  • Anticholinergics/muscarinic antagonists (biperiden, benztropine, trihexyphenidyl): useful in patients < 65 years with tremor as the main complaint

Administration of anticholinergics may worsen existing psychiatric symptoms (particularly dementia)! There is also a risk of ischuria!

Patients over the age of 65 or multimorbid patients of any age

• First-line treatment: levodopa + decarboxylase inhibitor (carbidopa)

Levodopa is best taken between meals (e.g., 30 minutes before a meal). High protein binding properties are responsible for decreased activity!

Patients with severe motor fluctuation

• Duodopa^TM pump
• Deep brain stimulation (see below)

Treatment of associated symptoms

• Depressive moods: SSRIs (e.g., citalopram) or SNRIs (e.g., venlafaxine)
• Dementia: cholinesterase inhibitors (e.g., donepezil)
• Psychotic episodes: atypical neuroleptics (e.g., clozapine)
• Dyskinesias: anticholinergics with CNS effects (e.g., trihexyphenidyl, benztropine)
• Detrusor hyperactivity: anticholinergics without significant CNS effects (e.g., trospium chloride)

Deep brain stimulation (DBS)

• Indication: primarily recommended for patients with severe motor symptoms who respond to levodopa treatment but are not sufficiently controlled by it (or if a decrease in dosage is necessary due to side effects)
• Adverse effects
  • Related to procedure and material: infections, hemorrhages, breakage or displacement of the electrode(s) or the lead(s)

References:^{[13][1][10][22][23][24][25][26][27]}