- Clinical science
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy in which microthrombi, consisting primarily of platelets, form and occlude the arterioles and capillaries. These occlusions result in the simultaneous occurrence of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (AKI). HUS predominantly affects children and is caused by bacterial toxins, most commonly the Shiga-like toxin of enterohemorrhagic Escherichia coli (E. coli) O157:H7. If there is strong suspicion of HUS based on clinical presentation and initial laboratory tests, treatment should begin immediately, as the condition may result in renal failure. Patients receive symptomatic treatment for renal symptoms, anemia, and complications affecting other organs, such as the brain and GI tract.
TTP), the other main type of thrombotic angiopathy, is discussed in the respective learning card.(
- Mainly children < 5 years of age
Epidemiological data refers to the US, unless otherwise specified.
- Bacterial exotoxins
- Streptococcus pneumoniae infection
Approx. 15% of children infected with E. coli O157:H7 will go on to develop HUS!
HUS is a thrombotic microangiopathy, a condition characterized by the formation of microthrombi occluding the microvasculature. The other main thrombotic microangiopathy is thrombotic thrombocytopenic purpura (TTP). The two conditions have some pathophysiology and clinical findings in common, but different etiologies. HUS is caused by bacterial toxins.
- Infection with enterohemorrhagic E. coli (EHEC) or another causative organism
- Mucosal inflammation facilitates bacterial toxins entering systemic circulation.
- Toxins cause endothelial cell damage (especially in the glomerulus ).
- Endothelial cell dysfunction: Damaged endothelial cells secrete cytokines that promote vasoconstriction and platelet microthrombus formation at the site of damage (intravascular coagulopathy).
- The glomerular filtration rate (GFR) decreases and RBCs are mechanically destroyed as they pass through the platelet microthrombi occluding small blood vessels (i.e., arterioles, capillaries) → hemolysis and end-organ ischemia and damage, especially in the kidneys
E. coli O157:H7 infection → Shiga-like toxin in systemic circulation → toxin-mediated endothelial injury → microthrombus formation → blockage of small vessels → RBC fragmentation (hemolysis) and end-organ damage
A diarrheal illness (usually bloody) for the past 5–10 days precedes the onset of HUS symptoms in many children. The triad of clinical findings occurring in HUS consists of: :
- Low platelets (i.e., thrombocytopenia)
- Microangiopathic hemolytic anemia
- Impaired renal function
- ↓ Platelets
↑ WBC count
- WBC differential may show left shift.
- ↓ Hemoglobin
- ↑ Reticulocytes
- Normal/slightly elevated prothrombin time (PT) and activated partial thromboplastin time (aPTT)
- ↑ Fibrin degradation products and D-dimer levels
- Large number of schistocytes on blood smear (up to 10% of RBCs)
- Serum chemistry
- Urinalysis: hematuria, proteinuria
|Differential diagnosis of platelet disorders|
|HUS||TTP||DIC) (||ITP) (||Bernard-Soulier syndrome||Glanzmann thrombasthenia|
|Pathophysiology|| || || || |
|Subjective state of patient|| || || || || || |
|Peripheral smear|| |
|PT (INR) and aPTT||↔︎/↑||↔︎/↑||↑↑||↔︎||↔︎||↔︎|
|D-Dimer, fibrin degradation products|| |
Other platelet disorders
- Acquired disorders of platelet function (e.g., drugs such as aspirin, NSAIDs; uremia, paraproteins)
- See also
The differential diagnoses listed here are not exhaustive.
- Avoid antibiotics and antimotility agents
- Monitor and correct
- Dialysis as indicated for AKI: Up to 50% of HUS patients require dialysis.
- Only in refractory cases: plasma exchange therapy
- Eculizumab : may be beneficial in HUS with neurological symptoms
- Post-diarrheal HUS is a nationally notifiable condition.
Platelet transfusions should be administered with caution unless patients are bleeding or require an invasive procedure. Some studies suggest that they can exacerbate microangiopathy!
HUS can result in microthrombus formation and complications in various organs
- CNS: : seizures, coma, stroke, paresis
- GI tract: hemorrhagic colitis; bowel necrosis, perforation, stricture; peritonitis; intussusception
- Heart: ischemia and fluid overload
- Pancreas: transient or permanent diabetes mellitus
- Liver: hepatomegaly, transaminase elevations
- Kidney: hypertension, chronic kidney disease (CKD), end-stage renal disease (ESRD)
We list the most important complications. The selection is not exhaustive.
- With treatment, the mortality rate of HUS is low: < 5%
- Long-term renal sequelae occur in 5–25% of children with HUS .