- Clinical science
Bowel obstruction is the interruption of the normal passage of bowel contents either due to a functional decrease in peristalsis or mechanical obstruction. Functional bowel obstruction, or paralytic ileus, is a temporary disturbance of peristalsis in the absence of mechanical obstruction. Postoperative ileus is the most common cause of paralytic ileus, which can also be caused by metabolic disturbances (e.g., hypokalemia), endocrinopathies (e.g., hypothyroidism), and certain drugs (e.g., anticholinergics). Mechanical bowel obstruction is classified according to the location as either small bowel obstruction (SBO) or large bowel obstruction (LBO) and, depending on the severity of obstruction, as either partial or complete. The most common cause of SBO is postoperative bowel adhesions, while the most common cause of LBO is malignant tumors. Regardless of the cause, bowel obstruction typically manifests with nausea, vomiting, abdominal pain, abdominal distention, and constipation or obstipation. In paralytic ileus, bowel sounds are usually absent on auscultation, whereas a high-pitched tinkling sound would be heard in the early phase of a mechanical bowel obstruction. Bowel distention leads to third-space volume loss, resulting in dehydration and electrolyte abnormalities. Symptoms are less severe in partial bowel obstruction. Diagnosis is confirmed on imaging with contrast-enhanced CT scan and abdominal x-rays. Typical findings in mechanical bowel obstruction include dilated bowel loops proximal to the obstruction, collapse of bowel loops distal to the obstruction, and, on contrast-enhanced imaging, a cut-off or transition point at the site of obstruction. In paralytic ileus, findings include generalized dilatation of bowel loops with no transition point and air that is visible in the rectum. Additional laboratory tests include CBC and BGA for the assessment of infection, electrolyte imbalances (e.g., hypokalemia), and metabolic imbalances (e.g., alkalosis). Surgical intervention (i.e., exploratory laparotomy) is recommended for suspected closed-loop bowel obstruction, if there are signs of perforation or peritonitis, or if there is no improvement following conservative management. In all other cases, conservative treatment is usually successful and involves bowel rest, gastric decompression (nasogastric suction), fluid resuscitation, and correction of electrolyte abnormalities.
|Small bowel obstruction (SBO)||Large bowel obstruction (LBO)|
|Etiology|| || |
|Findings on imaging|| |
An interruption in the normal passage of bowel contents.
- Mechanical bowel obstruction: an interruption in the normal passage of intestinal contents due to a structural barrier (e.g., bowel cancer, adhesions)
- Paralytic ileus: a temporary impairment of peristalsis in the absence of a mechanical obstruction
Degree of obstruction
- Partial bowel obstruction: bowel obstruction in which passage of some intestinal content through the blocked segment is possible
- Complete bowel obstruction: total interruption of the passage of intestinal contents
- Closed loop obstruction: a type of complete mechanical bowel obstruction in which a segment of bowel is occluded at two contiguous points (e.g., )
Site of obstruction
- Small bowel obstruction (SBO): obstruction occurring in the duodenum, jejunum, or ileum
- Large bowel obstruction (LBO): obstruction occurring in the cecum, colon, or rectum
- Simple bowel obstruction: obstruction without evidence of bowel ischemia
- Strangulated bowel obstruction: obstruction with compromised intestinal blood flow, resulting in bowel ischemia
Etiology  
|Small bowel obstruction||Large bowel obstruction|
|Most common causes|
|Specific to infants and children|
- Bowel obstruction → stasis of luminal contents and gas proximal to the obstruction → ↑ intraluminal pressure, which leads to the following:
- Gaseous abdominal distention → sequestration of fluids within the distended bowel loops (dehydration and hypovolemia) →
- Vomiting → loss of fluid and Na+, K+, H+, and Cl- → hypokalemia, metabolic alkalosis, and hypovolemia
Compression of intestinal veins and lymphatics → bowel wall edema → compression of intestinal arterioles and capillaries → bowel ischemia
- → ↑ Bowel wall permeability → translocation of intestinal microbes to the peritoneal cavity → sepsis
- → Necrosis and perforation of the bowel wall → peritonitis
- → Anaerobic metabolism and lysis of ischemic cells → accumulation of lactic acid and release of intracellular K+→ metabolic acidosis and hyperkalemia
Clinical features 
|Abdominal pain|| || |
|Vomiting/nausea|| || |
|Constipation or obstipation|| || |
|Abdominal distention|| || |
Partial bowel obstruction causes gradually progressive symptoms that are milder than those of complete obstruction. Obstipation is absent in partial bowel obstruction.
In the workup of suspected mechanical bowel obstruction, imaging allows for quick confirmation of the diagnosis as well as detection of conditions requiring immediate surgery (e.g., perforation). Laboratory tests may further help to assess the severity of the condition (e.g., electrolyte imbalance due to vomiting).
- If recurrent vomiting
- If bowel strangulation
- Neutrophilic leukocytosis (left shift)
- If dehydration: ↑ Hct
- If sepsis: abnormal coagulation profile
- Potentially prerenal azotemia
Consists of erect and supine abdominal x-rays and an erect chest x-ray.
- Indication: Best initial test in hemodynamically unstable patients or in resource-poor health centers
- Dilatation of bowel loops proximal to the obstruction
- Minimal/no air within the bowel loops distal to the obstruction
Stepladder sign (x-ray)
- Multiple air-fluid levels and a stacked appearance of dilated small bowel loops
- Best seen on an erect abdominal x-ray
CT abdomen and pelvis
More sensitive than x-ray
- With IV and oral contrast: Best initial test in hemodynamically stable patients with suspected partial bowel obstruction  
- With IV contrast: Indicated in patients with suspected complete bowel obstruction.
- Non-contrast: Indicated in patients with contrast-allergy and suspected complete bowel obstruction.
MRI abdomen and pelvis (with and/or without IV contrast) 
- Indication: patients who have a contraindication for radiation exposure
- Findings: similar to CT
- Indication: critically ill patients (easy bedside test) or patients with a suspected SBO and a contraindication for CT (e.g., contrast allergy) or radiation exposure (e.g., pregnancy)
Barium or water-soluble contrast enema
- Indication: in suspected distal LBO
When imaging with contrast (CT, enema) and perforation is expected, use water-soluble oral contrast.
- Fluid resuscitation, correction of electrolyte imbalance
- Intestinal decompression: nasogastric tube insertion
- Bowel rest (NPO)
- Administration of IV analgesics and antiemetics
- Gradual increase of oral intake, starting with clear fluids, can be initiated once the abdominal pain and distention subside and bowel sounds return to normal.
- Etiology-specific treatments
Procedure: exploratory laparotomy
- Restoration of intestinal transit: depends on intraoperative findings
- If bowel resection is required, the intervention may be carried out in a single procedure with anastomosis or permanent ostomy creation, or in a multistaged procedure with a temporary diverting ostomy.
Bowel obstruction requires a swift workup to establish whether emergent surgery is necessary!
- 100% mortality in cases of untreated intestinal strangulation
- Mortality rate for those undergoing surgery: 8–25%
- High risk of recurrence, particularly with chronic or recurring etiologies (Crohn disease, adhesions, radiation enteritis, volvulus, etc.)
- Paralytic ileus: temporarily impaired peristalsis of the gastrointestinal tract in the absence of mechanical obstruction
- Intra-abdominal surgery (postoperative ileus)
- Abdominal trauma; (e.g., due to retroperitoneal hemorrhage)
- Endocrine abnormalities (e.g., hypothyroidism, porphyria, uremia)
- Electrolyte disturbances (e.g., hypokalemia)
- Neuropathy (e.g., diabetes mellitus, spinal injury)
- Neurosurgical procedures (e.g., spinal surgery)
- Vascular diseases (e.g., mesenteric ischemia)
- Inflammation of intra-abdominal organs (e.g., appendicitis, cholecystitis, pancreatitis, severe gastroenteritis)
- Medications (e.g., anticholinergics, opioids, antidepressants)
- Stressful stimuli to the bowel (e.g., surgery, peritonitis) → sympathetic nervous system activation → decreased/arrested peristalsis
- Inflammation or intraoperative manipulation → local release of nitric oxide → relaxation of intestinal smooth muscles → decreased/arrested peristalsis
- Decreased/arrested peristalsis → bowel wall distention → progresses as detailed above in mechanical bowel obstruction
- Continuous (noncolicky) abdominal pain or discomfort
- Nausea, vomiting
- Abdominal distention
- Percussion: tympany
- Palpation: no tenderness unless peritonitis is present
- Auscultation: bowel sounds are absent (silent abdomen) or decreased (early paralytic ileus)
- Leukocytosis with left shift suggests intestinal infection or ischemia.
- Anemia may be a sign of intra-abdominal hemorrhage (e.g., in postoperative or trauma patients).
- Hypokalemia, hypomagnesemia
- Abdominal x-ray: best initial test
- Abdominal CT: to rule out suspected mechanical bowel obstruction or if abdominal x-ray is inconclusive
Conservative treatment: in patients with no signs of localized or diffuse sepsis (e.g., appendicitis, secondary peritonitis)
- Bowel rest
- Nasogastric tube insertion
- IV fluids and electrolyte repletion
- Stop or decrease causative medications (e.g., opioids).
- Gradual increase in enteral feeding as tolerated by the patient
- Early postoperative ambulation (although still recommended to prevent DVT) and use of prokinetics have not been proven to improve peristalsis.
- Surgical intervention: in patients with signs of peritonitis (e.g., appendectomy, exploratory laparotomy)
A change in the character of pain (colicky pain becoming continuous), rebound tenderness on examination, and/or signs of sepsis in a patient with bowel obstruction indicate the onset of complications and necessitate emergency surgical intervention!
We list the most important complications. The selection is not exhaustive.