Gonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae that leads to genitourinary tract infections such as urethritis, cervicitis, pelvic inflammatory disease (PID) and epididymitis. The disease primarily affects individuals between 15–24 years of age and has an incubation period of 2–7 days. Gonorrhea is commonly asymptomatic, especially in women, which increases the chance of further spreading and complications. In symptomatic cases, typical clinical symptoms include purulent vaginal or urethral discharge, dysuria, and signs of epdidymitis (e.g., scrotal pain) or PID (e.g., pelvic pain, dyspareunia). Gonorrhea may also cause extragenitourinary manifestations, such as proctitis and pharyngitis. Rarely, disseminated disease may occur, which typically manifests with a triad of arthritis, pustular skin lesions, and tenosynovitis. Diagnostic tests include nucleic acid amplification testing, gram stains, and bacterial cultures from urine or swabs of the genitourinary tract as well as blood and synovial fluid in disseminated infection. Treatment consists of antibiotics, mainly ceftriaxone and doxycycline, but may require different approaches in more severe cases. Without treatment, prolonged infection may lead to complications, such as a hymenal and tubal synechiae that lead to infertility in women.
- Sexual (oral, genital, or anal)
- Risk factors
- Men who have sex with men (MSM)
- Individuals with low socioeconomic status
- An asymptomatic course is common, particularly in women, and increases the risk of further spread and complications.
- Incubation time: 2–7 days
- In male individuals
In female individuals
- PID) (
- Bartholinitis: pain, edema, and discharge of the labia
- Vulvovaginitis may occur but is rare.
- Pharyngitis (sore throat, pharyngeal exudate, cervical lymphadenitis)
- Gonococcal proctitis
- Gonococcal conjunctivitis: may affect adults or neonates
Disseminated gonococcal infection (DGI)
- ∼ 2% of cases
- Most common in individuals < 40 years old and female individuals (4:1)
Clinical features: Two distinct clinical presentations are possible.
- Polyarthralgias: migratory, asymmetric arthritis that may become purulent
- Tenosynovitis: simultaneous inflammation of several tendons (e.g., fingers, toes, wrist, ankle)
Dermatitis: vesicular, pustular, or maculopapular lesions, possibly with a necrotic or hemorrhagic center
- Most commonly distributed on the trunk, extremities (sometimes involving the palms and soles)
- Typically < 10 lesions with a transient course (subside in 3–4 days)
- Additional manifestations: fever and chills (especially in the acute phase)
- Purulent gonococcal arthritis
- Genitourinary manifestations in only 25% of affected individuals
- Not to be confused with
- Arthritis-dermatitis syndrome
- Specimens for testing include
- Test of choice: nucleic acid amplification testing (NAAT)
- Additionally for arthritis: synovial fluid analysis
- Screening for gonorrhea (USPSTF recommendations)
- Uncomplicated gonorrhea 
- Complicated gonorrhea: : single-dose ceftriaxone IM PLUS doxycycline PO for 10–14 days
In all patients: Evaluate and treat the patient's sexual partners from the past 60 days.
- Treat the patient's sexual partners with a single-dose ceftriaxone IM.
- Provide if the timely evaluation of sexual partners is not feasible. 
Sexual partners must be treated simultaneously to avoid reinfections.