• Clinical science

Cerebellar syndromes


The cerebellum is the region of the brain responsible for controlling stance, gait, and balance, as well as the coordination of complex and goal-directed movements. The acute onset of cerebellar symptoms is considered a medical emergency and is usually due to stroke, hemorrhage, or cerebral edema. Chronic cerebellar syndromes are either acquired (e.g., alcoholism, tumors, paraneoplastic) or genetic. Cerebellar injury is characterized by impaired cerebellar function, resulting in ataxia, imbalance, uncoordinated movements (dysmetria), speech (dysarthria), and oculomotor disorders (nystagmus). Vertigo may also occur if the vestibulocerebellar system is affected. The diagnosis is based on the evaluation of these symptoms and is confirmed by detection of the underlying cause in imaging or laboratory or genetic tests. As treatment of these causes is often not possible, management is focused on supportive measures such as physiotherapy and psychological support groups.



Clinical features

The clinical features vary depending on the underlying cause and severity of cerebellar injury. Symptoms manifest ipsilaterally to the lesion site.

The localization of symptoms offers important diagnostic clues! Unilateral abnormalities in ocular movements, ataxia, and posture indicate a cerebellar lesion on the ipsilateral side!


Cerebellar syndromes are primarily a clinical diagnosis, based especially on the evaluation of posture, gait, and movements. Imaging tests and laboratory studies confirm the diagnosis.

  1. Neuroimaging (CT/MRI): indicated to rule out infarction, hemorrhage, tumors, edema
  2. Laboratory testing: complete blood cell count; electrolytes, vitamin B12 levels, vitamin B1 levels
  3. Genetic testing: if other diagnostic tests are negative or inconclusive


Differential diagnoses

Differential diagnoses of ataxia
Cerebellar ataxia Sensory (spinal) ataxia Vestibular ataxia
Clinical features
  • See “Clinical features” above.
Romberg test (tests proprioception and vestibular function)
  • Unable to perform
  • Positive
  • Positive
Unterberger test (tests vestibular and cerebellar function)
  • Positive
  • Negative
  • Positive

The differential diagnoses listed here are not exhaustive.