• Clinical science

Budd-Chiari syndrome

Abstract

Budd-Chiari syndrome is a rare condition resulting from hepatic vein obstruction that leads to hepatomegaly, ascites, and abdominal discomfort. It is most commonly due to a thrombotic occlusion secondary to a chronic myeloproliferative neoplasm (e.g., polycythemia vera), but may be caused by other conditions associated with hypercoagulable states. The obstruction of blood flow causes congestion of the liver with subsequent liver cell damage. If left untreated, it may result in progressive liver failure. Doppler ultrasound confirms the diagnosis. Management involves preventing further clotting with anticoagulation therapy, restoring blood flow with radiologic or surgical procedures, and treating the underlying condition.

Etiology

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Pathophysiology

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Clinical features

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Diagnostics

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Treatment

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Complications

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We list the most important complications. The selection is not exhaustive.