Abbreviation: SSSS
A blistering skin disorder caused by exfoliative toxins produced by S. aureus following a local infection (e.g., pharyngitis, bullous impetigo). Typically affects children < 6 years. Fever and diffuse, tender erythema occur, followed by extensive flaccid intraepidermal blisters and sloughing off of the superficial layer of skin to reveal moist, red tissue underneath, giving the area a "scalded” appearance. Mucous membranes are typically spared.