Enterohepatic circulation

The circulation of hepatic metabolites (e.g., bile acids, bilirubin, drugs), which are first excreted into the intestine, then reabsorbed by enterocytes, and then transported back to the liver. Increased enterohepatic circulation, which can occur in conditions associated with decreased stool passage (e.g., breast milk jaundice, cystic fibrosis, Hirschsprung disease), can result in unconjugated hyperbilirubinemia.