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Uveal melanoma

Last updated: March 26, 2021

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Uveal melanoma is the most common primary malignant tumor of the eye. It develops from choroidal melanocytes and is therefore often pigmented. The tumor can arise from the choroid, iris, or ciliary body. Symptoms, which depend on the location of the tumor, begin when the tumor extends to the optical axis or if there is concomitant retinal detachment or interference with the function of the ciliary body or pupil. The condition is diagnosed through fundoscopy and ultrasonography. Treatment usually consists of radiation therapy or surgical removal of the tumor in advanced disease. With the exception of iris melanoma, uveal melanoma is typically diagnosed late because of the lack of early symptoms. Approximately half of patients go on to develop distant metastases via hematogenous spread, most commonly to the liver, which are then fatal.

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Epidemiological data refers to the US, unless otherwise specified.

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Symptoms vary depending on melanoma location.

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The differential diagnoses listed here are not exhaustive.

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We list the most important complications. The selection is not exhaustive.

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  1. Intraocular (Uveal) Melanoma Treatment (PDQ®) – Health Professional Version. https://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq. Updated: September 20, 2018. Accessed: December 2, 2018.
  2. Singh P, Singh A. Choroidal melanoma. Oman J Ophthalmol. 2012; 5 (1): p.3-9. doi: 10.4103/0974-620X.94718 . | Open in Read by QxMD
  3. Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V. Ocular melanoma: an overview of the current status. Int J Clin Exp Pathol. 2013; 6 (7): p.1230-44.
  4. Kivelä T. Diagnosis of uveal melanoma. KARGER ; 2011 : p. 1-15
  5. Grehn F. Augenheilkunde. Springer Verlag (2005) ; 2006
  6. Lang GK, et al.. Augenheilkunde. Thieme Verlag (2008) ; 2008