• Clinical science

Thyroid antibodies


Antithyroid antibodies are autoantibodies that target one or more components of the thyroid gland and can act as markers to help diagnose autoimmune thyroid conditions. For example, thyroid stimulating hormone receptor antibodies (TRAb) are seen mostly in Graves' disease, while thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) are typical for Hashimoto's thyroiditis (but may also be present in Graves' disease). However, elevated thyroid antibodies do not always indicate disease, as somewhat increased levels may also be present in healthy individuals.


Percentage of cases associated with positive autoantibodies for various conditions:

TSH receptor antibodies (TRAb) Thyroid peroxidase antibodies (TPOAb) Thyroglobulin antibodies (TgAb)
Graves' disease ∼ 90% ∼ 70% ∼ 50–70%
Hashimoto's thyroiditis ∼ 10–15% > 90% > 80%
Thyroid cancer No association Sporadic ∼ 25% (important for follow-up!)
Other conditions

∼ 15% in multinodular goiter

> 60% in postpartum thyroiditis ∼ 40% in other autoimmune diseases (eg, type 1 diabetes mellitus)
General population Negative ∼ 5% ∼ 5%




  • 1. Kasper DL, Fauci AS, Hauser SL, Longo DL, Lameson JL, Loscalzo J. Harrison's Principles of Internal Medicine. New York, NY: McGraw-Hill Education; 2015.
  • 2. Tuttle RM, Ross DS, Mulder JE. Differentiated Thyroid Cancer: Overview of Management. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. https://www.uptodate.com/contents/differentiated-thyroid-cancer-overview-of-management. Last updated May 12, 2016. Accessed February 1, 2017.
  • 3. Burman KD, Ross DS, Mulder JE. Postpartum Thyroiditis. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. http://www.uptodate.com/contents/postpartum-thyroiditis. Last updated January 25, 2017. Accessed February 9, 2017.
  • 4. Elhomsy G, Staros EB. Antithyroid Antibody . In: Antithyroid Antibody . New York, NY: WebMD. http://emedicine.medscape.com/article/2086819. Updated December 4, 2014. Accessed September 10, 2017.
  • 5. Trbojević B, Djurica S. Diagnosis of autoimmune thyroid disease. Srp Arh Celok Lek. . 2005; 133(1): pp. 25–33. pmid: 16405253.
  • 6. Toyoda N, Nishikawa M, Iwasaka T. Anti-thyroglobulin antibodies. Nihon Rinsho. 1999; 57(8): pp. 1810–1814. pmid: 10483256.
  • 7. Poduval J. Thyroglobulin. In: Staros EB. Thyroglobulin. New York, NY: WebMD. http://emedicine.medscape.com/article/2089532-overview#showall. Updated January 17, 2014. Accessed January 26, 2017.
  • 8. Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J. Harrisons's Principles of Internal Medicine, 18th Edition, 2011. McGraw-Hill Medical; 2011.
  • 9. Cho BY. Clinical applications of TSH receptor antibodies in thyroid diseases. J Korean Med Sci. 2002; 17(3): pp. 293–301. doi: 10.3346/jkms.2002.17.3.293.
  • 10. Chiovato L, Bassi P, Santini F, et al. Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis. J Clin Endocrinol Metab. . 1993; 77(6): pp. 1700–1705. doi: 10.1210/jcem.77.6.7903315.
  • 11. Morshed S, Davies T. Graves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies. Hormone and Metabolic Research. 2015; 47(10): pp. 727–734. doi: 10.1055/s-0035-1559633.
  • Herold G. Internal Medicine. Cologne, Germany: Herold G; 2014.
  • Orgiazzi J. Anti-TSH receptor antibodies in clinical practice. Endocrinol Metab Clin North Am. 2000; 29(2): pp. 339–355. pmid: 10874533.
last updated 11/24/2019
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