Rubella, or German measles, is an infectious disease that is caused by the rubella virus. Since the introduction of the measles, mumps, and rubella (MMR) vaccine, it is a relatively rare condition. Rubella is transmitted via airborne droplets and has a mild clinical course. The clinical presentation begins with nonspecific flu-like symptoms and post-auricular and/or suboccipital lymphadenopathy. An exanthem phase may overlap or follow; this phase is characterized by a rash that typically starts behind the ears and progresses distally, developing into a generalized maculopapular rash. Rubella is usually self-limiting and involves symptomatic treatment. Immunization with a live, attenuated vaccine, in association with the measles and mumps vaccine, is highly recommended. The first dose is administered between 12–15 months of age and the second dose between 4–6 years of age. Complications of infection during pregnancy may cause congenital rubella syndrome with severe malformations (e.g., hearing loss, cataracts, heart defects, intellectual disabilities).
- A rare disease in the US following the implementation of the MMR vaccine
Epidemiological data refers to the US, unless otherwise specified.
- Route of transmission
Patients with rubella infection are asymptomatic in ∼ 50% of cases. Young children have a far milder course than older children and adults; the latter group often presents with prodromal symptoms, other systemic complaints (e.g., arthritis), and a longer duration of infection.
- Incubation period: 2–3 weeks after infection
- Duration: 1–5 days
- Duration: lasts 2–3 days
Although rubella infection may be considered a clinical diagnosis; , laboratory confirmation is necessary for certain patient groups to assess the risk of complications such as e.g., congenital rubella in pregnant women or encephalitis.
The differential diagnoses listed here are not exhaustive.
- Severe pruritis: antihistamines
- Severe polyarthritis: rest and nonsteroidal anti-inflammatory drugs
- For treatment of congenital rubella syndrome and seronegative women following exposure to rubella virus, see
- Chronic arthritis (especially women)
- Thrombocytopenic purpura
- Rubella during pregnancy (TORCH infection):
- Rare: rubella , , , ,
We list the most important complications. The selection is not exhaustive.
- Live attenuated virus that is administered in combination with the measles and mumps vaccine (see )
- Two vaccinations are recommended because of potential non-responders (5%):
- First dose: 12–15 months of age
- Second dose: 4–6 years of age or at least 28 days following the first dose.
- Check vaccination status
Precautions during infection
- Patients with rubella infection should be isolated for 7 days after the onset of the rash.
- Precautions regarding droplet transmission should be taken.