- Clinical science
Myelopathies are neurological disorders due to compression of the spinal cord. Myelopathies can be cervical, thoracic, or lumbar. Cervical myelopathy is the most common type of myelopathy in adults above 55 years of age. Etiologies include degenerative changes of the spine, spinal trauma, infection, tumors, and autoimmune disorders. Onset can be acute, step-wise, or insidious. Clinical features vary depending on the level of the lesion and include local pain, stiffness, and impaired sensation, hypotonia, and hyporeflexia at the level of the lesion, and spasticity and hyperreflexia below the level of the injury level. Diagnosis is confirmed by MRI or myelography. Treatment includes conservative management for degenerative disease or immediate surgical decompression in acute compression.
- Causes for compression of the spinal cord include:
- Blunt or penetrating trauma (e.g., fracture, )
- Infection (e.g., abscess)
- Radiation therapy
- Autoimmune disorders (e.g., , )
- Neoplasms (e.g., meningiomas, nerve sheath tumors, metastases) or cysts (e.g., epidermoid cysts)
- Ossification of the posterior longitudinal ligament (OPLL)
- Congenital narrowing of the cervical spinal canal
- Discogenic myelopathy (central )
- Cervical myelopathy (most common cause of myelopathy in adults over 55 years of age)
- Thoracic myelopathy
- Lumbar myelopathy (rare)
Features depend on the level of compression and the onset may be sudden (e.g., with trauma), step-wise, or slowly progressive (e.g., degenerative diseases)
- Neck, shoulder, upper limb, or lower limb pain (neck stiffness may be present)
- Signs and symptoms of at the level of the lesion; (e.g., weakness and atrophy in the arms and/or hands in lesions of the thoracic spine)
- Signs and symptoms of an below the level of the lesion; (e.g., abnormal spastic gait is often an early sign; hyperreflexia or a positive may be present)
- Impaired sensation; (e.g., numbness; , impaired proprioception, ataxia)
- Impaired bladder and bowel control
Damage to the spinal cord and the nerve roots (radiculopathy) often occur simultaneously!
Pain is not commonly an early symptom. Therefore patients may not be diagnosed until myelopathy becomes severe!
- MRI of the spine: : determines the site of narrowing of the medulla and the underlying pathology
- Myelography: (possibly with CT): when MRI is contraindicated (e.g., in patients with metal implants)
- Consider electromyography, nerve conduction studies, and somatosensory evoked potentials of the median and tibial nerve (evaluates nerve functions for providing sensation and motor control to arms and legs)
- Postvoid residual ultrasound: in case of bladder dysfunction
The differential diagnoses listed here are not exhaustive.
- Conservative treatment: (i.e., analgesia; , corticosteroid; therapy , bracing; , physiotherapy; ): indicated perioperatively; , for severe cases (e.g., degenerative cervical myelopathy ), and mild cases
- Decompression surgery: : typically indicated in acute or advanced cases