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Mycosis fungoides

Last updated: October 16, 2020

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Mycosis fungoides is an indolent, CD4+ cutaneous T-cell lymphoma that presents on the skin. It is characterized by scaly, pruritic, well-demarcated skin plaques and patches that are refractory to initial treatment. In the later stages of the disease, mushroom-shaped tumors develop within the plaque lesions, and ultimately lymphadenopathy and hepatosplenomegaly can develop. Mycosis fungoides, which is based on the fungus-like growth pattern of the lesions, is misleading as the disease is not fungal in origin. Histopathological evidence is essential for diagnosis and typically consists of atypical lymphocytes found in the upper dermis or aggregates of such cells within the epidermis (known as Pautrier microabscesses). Early treatment consists of topical glucocorticoids, while treatment for later stages involves a combination of localized radiation, electron beam therapy, and systemic chemotherapy. Sézary syndrome, a cutaneous T-cell lymphoma with leukemic dissemination of mutated T cells can be an advanced form of mycosis fungoides or arise de novo.

Epidemiological data refers to the US, unless otherwise specified.

Sézary syndrome

The leukemic dissemination present in Sézary syndrome distinguishes it from mycosis fungoides.

Adult T-cell leukemia (ATL) [6]

Eczema

The differential diagnoses listed here are not exhaustive.

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