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Mallory-Weiss syndrome

Last updated: March 11, 2021

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Mallory-Weiss syndrome refers to acute upper gastrointestinal bleeding caused by mucous membrane lacerations at the gastroesophageal junction, although it may extend above or below. Forceful vomiting in the presence of a damaged gastric mucous membrane, often related to alcoholism, is a common cause of Mallory-Weiss syndrome. Patients typically present with a history of epigastric pain and hematemesis. Esophagogastroduodenoscopy is important in both the diagnosis of the condition and its treatment, which involves simultaneous hemostasis.

Think of the double L in MaLLory-Weiss to remember Longitudinal Lacerations.

Epidemiological data refers to the US, unless otherwise specified.

The differential diagnoses listed here are not exhaustive.

General measures

  • If bleedings stops spontaneously conservative treatment is usually sufficient
  • Control of precipitating factors (e.g., omeprazole for GERD)
  • Inpatient monitoring
  • Treat hemodynamic instability if present

Surgical treatment

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  3. Mallory Weiss Syndrome. Updated: November 24, 2019. Accessed: January 6, 2020.
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  5. Herold G. Internal Medicine. Herold G ; 2014