• Clinical science

Coxsackie virus infections


Coxsackie viruses are a group of RNA viruses with over 20 serotypes; depending on specific viral characteristics, these serotypes are further divided into groups A and B. Infection is associated with a wide range of symptoms, which are dependent on the exact serotype. Hand, foot, and mouth disease (HFMD) and herpangina are commonly caused by group A coxsackie viruses, while pleurodynia and myocarditis are caused by group B coxsackie viruses. Both groups may cause viral meningitis, conjunctivitis, or flu‑like symptoms. Diagnostic procedures and treatment should be tailored to the specific disease manifestation.


  • Worldwide distribution
  • Occur in all age groups
  • Highest incidence in infants and young children (< 10 years)


Epidemiological data refers to the US, unless otherwise specified.


  • Pathogen: Coxsackie virus
  • Route of transmission
    • Airborne droplets
    • Fecal‑oral route


Disease manifestations

Coxsackie B is the most common cause of viral myocarditis!