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Autoantibodies in rheumatic diseases

Last updated: March 18, 2021

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Antibody diagnostics play a vital role in the differential diagnosis of rheumatic diseases. Many of these autoantibodies can be differentiated into antibodies against nuclear antigens (ANAs) and antibodies against cytoplasmic antigens (ANCAs). Although both of these antibodies are detectable in numerous autoimmune diseases, elevated ANAs are typical for connective tissue diseases and elevated ANCAs for vasculitis. Diagnosis of individual conditions can be further supported by detecting disease-specific ANAs or ANCAs, such as anti-dsDNA in systemic lupus erythematosus or c-ANCA in granulomatosis with polyangiitis.

Connective tissue diseases

Specific ANA

Other autoantibodies

Systemic lupus erythematosus (SLE)

Systemic sclerosis (scleroderma)

Sjögren syndrome

Polymyositis and dermatomyositis

  • RF

Mixed connective tissue disease

  • Anti-U1-RNP
  • RF

References:[1][2]

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  2. Baer AN. Diagnosis and Classification of Sjögren's Syndrome. In: Post TW, ed. UpToDate. Waltham, MA: UpToDate. http://www.uptodate.com/contents/diagnosis-and-classification-of-sjogrens-syndrome.Last updated: March 15, 2016. Accessed: April 9, 2017.
  3. Ying C-M, Yao D-T, Ding H-H, Yang C-D. Infective Endocarditis with Antineutrophil Cytoplasmic Antibody: Report of 13 Cases and Literature Review. PLoS ONE. 2014; 9 (2): p.e89777. doi: 10.1371/journal.pone.0089777 . | Open in Read by QxMD
  4. Herold G. Internal Medicine. Herold G ; 2014